We tested over 43 brands to find the BEST Methylene Blue supplements that actually work.

By Kimberly Webber

(RBC) – It’s an age-old problem… quite literally! Fatigue, lack of focus, and low energy can hit at any age, but for most people, these issues accelerate as the years add up. For as long as people have wanted sharper thinking and stronger energy, we’ve been trying to figure out how to restore the body and mind at a cellular level.

Luckily, there are now powerful solutions designed to support mitochondria, improve cognition, and energize the brain and body. But how do you choose which products to try?

How do you know which will work and which won’t? That’s where we come in!

Methylene Blue Drops are highly concentrated liquid formulas designed to target cellular energy production, enhance memory, and fight oxidative stress. Of course, every formula is different — and some work much better than others.

We’ve tested dozens of Methylene Blue products to determine our TOP FIVE choices.

We compared effectiveness, safety, and price to make sure you find the Methylene Blue Drops that are right for you!

Let’s get started!

Effectiveness: 99%

Safety: 100%

Price: $

Overall: A+

This is by far our favorite choice when it comes to a simple daily drop that can recharge your cells, enhance mitochondrial function, and support sharper focus and long-lasting energy.

Alphaura’s Methylene Blue is one of the only formulas backed by decades of clinical research showing its ability to improve memory, boost ATP production, protect against oxidative stress, and enhance overall brain performance.

Alphaura’s Methylene Blue is best for people struggling with brain fog, low energy, sluggish thinking, or anyone looking for an all-in-one solution to support both mind and body vitality (with a 100% money-back guarantee if you don’t notice results in 60 days).

*our results using the Alphaura formulation, noticeable improvements in energy, focus, and mental clarity in just 3–6 weeks. (above)

Best of all, it was the only product on our list we found with a limited-time 50% off code, "SECRET50" — use this code at checkout for 50% off! (this code isn’t advertised online, and in the past it’s been taken down, but it is working as of today.)

This made it one of the most affordable products on the market for one that actually works. Give it a try using the discount and let us know your results!

"Alphaura’s Methylene Blue is the most advanced and effective solution for boosting energy, focus, and cellular health."

-Dr. Lou Cayano | Santa Monica MD

Effectiveness: 85%

Safety: 85%

Price: $$$$

Overall: B+

10X Health’s Methylene Blue Drops are a solid option for cellular energy and focus support. We do like this product, but it’s quite expensive for similar results as Alphaura and other brands. If you’re willing to pay the higher price, it can be worth trying—but Alphaura’s Methylene Blue is still the superior choice in both value and effectiveness.

Effectiveness: 85%

Safety: 82%

Price: $$$$

Overall: B+

Ultra Methylene Blue is decent for those just starting their nootropic or energy journey, who don’t need major results but want to try something simple. It doesn’t deliver the same purity or clinically backed performance as other formulas, like Alphaura’s Methylene Blue, but it’s still a passable option.

Effectiveness: 80%

Safety: 80%

Price: $$$

Overall: B

Vital Methylene Blue offers a straightforward formula for those looking to support energy and focus, and it does the job decently. While the drops are effective enough for light use, they’re on the pricey side and don’t provide the same level of purity, research, or noticeable results as Alphaura’s Methylene Blue, which remains the superior choice.

Effectiveness: 80%

Safety: 80%

Price: $

Overall: B+

Nootlyn’s Methylene Blue is set at a very affordable price and does include a concentrated formula. The main goal is to support cellular energy and focus, but while we like the cost and reviews, we haven’t seen the same level of results you can get with other products. Alphaura’s Methylene Blue, at a similar price point and backed by far more proven results, delivers effects well beyond what Nootlyn offers.

While we feel we recommended some great cognitive and energy supplements to help improve focus, restore vitality, and recharge cellular energy, we believe Alphaura’s product was the top choice. We wanted to talk further with our investigative reporter, Stephanie Marianne, who helped create the rankings list and personally tested Alphaura’s Methylene Blue. Stephanie tells the story.

Personally, I never believed in the effectiveness of any so-called “brain boosters” or “anti-aging” products. “You can’t fight time,” I used to tell my friends. Too many of them had been tricked into buying gimmick powders or overpriced capsules, only to find out it was all hype. So I avoided these supplements at all costs.

But then my best friend, who I trust with my life, swore by Alphaura’s Methylene Blue Drops. She added just a few drops to her daily routine, and after a couple weeks, she was sharper, more energized, and noticeably more focused. It was even more convincing when she showed me her journaling progress—her productivity, mental clarity, and mood all skyrocketed after using it consistently.

I had always been self-conscious about my brain fog and constant fatigue, so I begged her to let me try it. Instead, she gave me a secret 50% off code, SECRET50, and I ordered my own bottle immediately.

Two days later, my package arrived. The application couldn’t be simpler—you add a precise drop or two to a glass of water, stir, and drink. Within minutes, it absorbs into your system, supporting your cells and brain at the deepest level. That’s it!

HOW DOES ALPHAURA’S METHYLENE BLUE WORK?

I’ll be honest—I expected instant results. But like most things that work, it took a couple weeks before I really noticed a difference. In the meantime, I started researching exactly how Alphaura’s formula works and why it stands out from other “focus” supplements.

Methylene Blue is a mitochondrial optimizer. It enhances the way your cells produce ATP (your body’s energy currency), improves circulation to the brain, and acts as a powerful antioxidant to protect neurons from stress and aging.

It’s actually simple. Just as our bodies slow down as we age (remember how easy it was to pull all-nighters in your twenties?), our cells follow the same pattern. Mitochondria—the “power plants” of your cells—become less efficient, leading to fatigue, brain fog, and reduced performance.

Alphaura’s Methylene Blue works to restore optimal function by supercharging mitochondria, so your cells literally produce more usable energy. That means clearer thinking, faster recall, and a noticeable boost in daily stamina.

The key to sustained energy and focus starts with healthy mitochondria, and that’s exactly what Alphaura’s drops target. Backed by decades of research, Methylene Blue is one of the most studied compounds in neuroprotection and cellular health. Alphaura’s formulation uses ultra-pure, pharmaceutical-grade Methylene Blue—making it one of the safest and most effective supplements available today.

So, after about 4 weeks, I did a “check-in” with myself. And wow—the results were undeniable. My energy was steady throughout the day, I could work longer without crashing, and the fog that always clouded my mornings was gone. My mind felt sharper, faster, and more in control.

By far, Alphaura’s Methylene Blue is the safest and most effective supplement for cellular energy and cognitive support EVER.

"I’ve been using Alphaura’s Methylene Blue for just over a month and my focus at work has completely changed. No more brain fog in the mornings!" — Jessica, 26

"This is the best thing I’ve tried for energy. I used to crash every afternoon, but now I can push through my workouts and still feel sharp." — Ryan, 27

"By week 5, I noticed my memory and mood improving. It feels like my brain is finally firing on all cylinders again." — Sophia, 32